Answers revealed in the comments.
GAME 1
After San Diego, San Jose, and San Francisco, name two of the next five most-populous cities in California with names that begin with the letters “S-A-N”.
GAME 2
Dr. Watson, the assistant to Sherlock Holmes, has been portrayed on two different long-running TV series this decade, one that premiered in 2010, and another that premiered in 2012, neither of which has officially ended. Name both performers.
hebspeaks 
Game one answers:
Santa Ana
San Bernardino
Santa Clarita
Santa Rosa
Santa Clara
GAME 2 answers:
Martin Freeman
Lucy Liu