Answers revealed in the comments.
GAME 1
Which main nucleobase was first discovered in the 1840s in the excrement of sea birds?
GAME 2
The longest period of time that a state has been served by the same two U.S. senators is a little more than 36 years, from November 1966-January 2003. Which southeastern U.S. state had the same two senators for that entire period of time?
hebspeaks 
game one answer: guanine
game two answer: South Carolina